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Di Narzo AF, Kozlenkov A, Roussos P, Hao K, Hurd Y, Lewis DA, Sibille E, Siever LJ, Koonin E, Dracheva S. A unique gene expression signature associated with serotonin 2C receptor RNA editing in prefrontal cortex and altered in suicide. Human Molecular Genetics. 2014 April 29.

Soumier A, Sibille E. Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice. Neuropsychopharmacology. 2014 April:1-11.

Chang LC, Jamain S, Lin CW, Rujescu D, Tseng GC, Sibille E. A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. PLoS One. 2014 March; 3 (9): 1-11.


Chang LC, Lin HM, Sibille E, Tseng GC. Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline. BMC Bioinformatics. 2013 December; 14 (1): 368.

Diniz BS, Reynolds CF, Begley A, Dew MA,  Anderson SJ, Lotrich F, Erickson KI, Lopez O, Aizenstein H, Sibille E, Butters MA. Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study. Journal of Psychiatric Research. 20 November 2013. [Epub ahead of print]

Gaiteri C, Ding Y, French B, Tseng GC, Sibille E. Beyond modules & Hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders. Genes, Brain, and Behavior. 13 November 2013. [Epub ahead of print]

Seney ML, Ekong KI, Ding Y, Tseng GC, Sibille E. Sex chromosome complement regulates expression of mood-related genes. Biology of Sex Differences. 2013 November; 4 (1): 20. [Epub ahead of print]

Seney ML, Chang LC, Oh H, Wang X, Tseng GC, Lewis DA, Sibille E. The role of genetic sex in affect regulation and expression of GABA-related genes across species. Frontiers in Psychiatry. 2013 September; 104 (4):1-18. doi: 10.3389/fpsyt.2013.00104

Lin Li-Chun, Sibille E. Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target? Frontiers in Pharmacology. 2013 September; 110 (4): 1-12. doi: 10.3389/fphar.2013.00110

Sibille E, French B. Biological substrates underpinning diagnosis of major depression. International Journal of Neuropsychopharmacology. 2013 May; 14: 1-17. [Epub ahead of print]

Sibille E. Will Neurobiology Rise to the Translational Challenges and Opportunities of Late-life Geriatric Psychiatry? American Journal of Geriatric Psychiatry. 2013 May; 21 (5): 411-4. doi: 10.1016/j.jagp.2013.02.016.

Sibille E. Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders. Dialogues in Clinical Neuroscience. 2013 Mar; 15(1): 53-65.

McKinney, BC, Sibille E. The Age-by-Disease Interaction Hypothesis of Late-Life Depression. American Journal of Geriatric Psychiatry. 2013 May; 21 (5): 418-32. doi: 10.1016/j.jagp.2013.01.053. Epub 2013 Feb 6.

Douillard-Guilloux G, Guilloux JP, Lewis DA, Sibille E. Anticipated Brain Molecular Aging in Major Depression. American Journal of Geriatric Psychiatry. 2013 May; 21 (5): 450-60. doi: 10.1016/j.jagp.2013.01.040. Epub 2013 Feb 6.


D'Aiuto, Di Maio R, Heath B, Raimondi G, Milosevic J, Watson AM, Bamne M, Parks WT, Yang L, Lin B, Miki T, Mich-Basso JD, Arav-Boger R, Sibille E, Sabunciyan S, Yolken R, Nimgaonkar V. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS One. 2012;7(11):e49700. doi: 10.1371/journal.pone.0049700. [Epub 2012 Nov 27]

McKinney BC, Oh H, Sibille E. Age by Disease Biological Interactions: Implications for Late-Life Depression. Frontiers in Genetics of Aging. 2012 Nov 16; 3:237. doi:10.3389/fgene.2012.00237.

Tripp A, Oh H, Guilloux JP, Martinowich K, Lewis DA, Sibille E. Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. American Journal of Psychiatry. 2012 Nov 1; 169(11):1194-202. doi: 10.1176/appi.ajp.2012.12020248

  comment in: Kerman IA. New insights into BDNF signaling: relevance to major depression and antidepressant action. American Journal of Psychiatry. 2012 Nov 1; 169(11):1137-40. 

Wang X, Kang DD, Shen K, Song C, Lu S, Chang LC, Liao SG, Huo Z, Tang S, Kaminski N, Sibille E, Lin Y, Li J, Tseng GC. An R package Suite for Microarray Meta-analysis in Quality Control, Differentially Expressed Gene Analysis and Pathway Enrichment Detection. Bioinformatics. 2012 Aug 3. [Epub ahead of print] PMID: 22863766

Edgar N, Sibille E. A Putative Role for Oligodendrocytes in Mood Regulation. Translational Psychiatry. 2012 2, e109 doi:10.1038/tp.2012.34

Wang X, Lin Y, Song C, Sibille E, Tseng GC. Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis; with application to major depressive disorder. BMC Bioinformatics. 2012 13:52 http://www.biomedcentral.com/1471-2105/13/52

Inna Gaisler-Salomon, Yvonne Wang, Nao Chuhma, Hong Zhang, Yaela Golumbic, Andra Mihali, Ottavio Arancio, Etienne Sibille, Stephen Rayport. Synaptic Underpinnings of Altered Hippocampal Function in Glutaminase-Deficient Mice During Maturation. Hippocampus. 2012 DOI 10.1002/hipo.22014.

Marianne Seney, Christopher Walsh, Ryan Stolakis, Etienne Sibille. Neonatal testosterone partially organizes sex differences in stress-induced emotionality in mice. Neurobiology of Disease. 2012 doi:10.1016/j.nbd.2012.02.014.

Jennifer Joeyen-Waldorf, Yuliya S. Nikolova, Nicole Edgar, Chris Walsh, Rama Kota, David A. Lewis, Robert Ferrell Stephen B. Manuck, Ahmad R. Hariri, Etienne Sibille. Adenylate Cyclase 7 is Implicated in the Biology of Depression and Modulation of Affective Neural Circuitry. Biological Psychiatry. 2012 doi:10.1016/j.biopsych.2011.11.029.

  Supplemental Information

  comment in: Boris Tabakoff and Paula Hoffman. Transducing Emotionality: The Role of Adenylyl Cyclases. Biological Psychiatry. 2012 71:572-573 


Almeida JRC, Kronhaus DM, Sibille E, Langenecker SA, Versace A, LaBarbara EJ, Phillips ML. Abnormal left-sided orbitomedial prefrontal crotical-amygdala connectivity during happy and fear face processing: a potential neural mechanism for female MDD. Frontiers in Psychiatry. 2011 published December 08, doi: 10.3389/fpsyt.2011.00069.

David J. Kupfer, Jules Angst, Michael Berk, Faith Dickerson, Sophia Frangou, Ellen Frank, Benjamin I. Goldstein, Allison Harvey, Fouzia Laghrissi-Thode, Marion Leboyer, Michael J. Ostacher, Etienne Sibille, Stephen M. Strakowski, Trisha Suppes, Mauricio
Tohen, Robert H. Yolken, L. Trevor Young, and Carlos A. Zarate. Advances in bipolar disorder: selected sessions from the
2011 International Conference on Bipolar Disorder.
Annals of the New York Academy of Sciences, Issue: Annals Meeting Reports. 2011 doi:10.1111/j.1749-6632.2011.06336.x.

Kang D, Sibille E, Kaminski N, Tseng GC. MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis. Nucleic Acids Research. 2011 doi:10.1093/nar/gkr1071.

Edgar NM, Touma C, Palme R, Sibille E. Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1. Translational Psychiatry. 2011 advance online Sep 20.

Guilloux J-P, Doulliard-Guilloux G, Kota R, Wang X, Gardier AM, Martinowich K, Tseng GC, Lewis DA, Sibille E. Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Molecular Psychiatry. 2011 advance online Sep 13.

Gaiteri C, Sibille E. Differentially expressed genes in major depression reside on the periphery of resilient gene coexpression networks. Frontiers in Neuroscience. 2011 Aug 30.

Lin Li-Chun, Lewis DA, Sibille E. A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism. Molecular Brain. 2011 4:18.

Guilloux J-P, Seney M, Edgar N, Sibille E. Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex. J Neurosci Methods. 2011 Epub 2011 Jan 26.

Glorioso C, Sibille E. Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Progress in Neurobiology. 2011 (93)165-181.

Tripp A, Kota, R, Lewis DA, Sibille E. Reduced somatostatin in subgenual anterior cingulate cortex in major depression. Neurobiology of Disease. 2011 Epub 2011 Jan 11.

Sibille E, Morris H, Kota R, Lewis DA. GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. International Journal of Neuropsychopharmacology. 2011.


Glorioso C, Oh S, Douillard GG, Sibille E. Brain Molecular Aging, Promotion of Neurological Disease and Modulation by Sirtuin5 Longevity Gene Polymorphism. Neurobiology of Disease. 2010 Dec (41) 279-290.

Gaiteri C, Guilloux JP, Lewis DA, Sibille E. Altered Gene Synchrony Suggests a Combined Hormone-Mediated Dysregulated State in Major Depression. PloS One. 2010 Apr 1;5(4):e9970.

  Tripp A, Sibille E. Rodent behavioral models in serotonin transporter knockout: emotional dysregulation. In AV Kalueff (ed) Experimental Models in Serotonin Transporter Research, Cambridge University Press. 2010.

Guilloux JP, Gaiteri C, Sibille E. Network analysis of positional candidate genes of schizophrenia highlights…more than… myelin-related pathways. Mol Psychiatry. Epub 2010  March 30. PubMed PMID: 20351722.


  Sibille E, Wang Y, Joeyen-Waldorf J, Gaiteri C, Surget A, Oh S, Belzung C, Tseng GC, Lewis DA., M.D. A Molecular Signature of Depression in the Amygdala. Am J Psychiatry. 2009 Sep;166(9): 1011-24 Epub 2009 Jul 15. PubMed PMID: 19605536 

  Supplemental Information

  comment in: Evans SJ, Akil H, Watson SJ. Analyzing Gene Expression in Depression. Am J Psychiatry. 2009 Sep;166(9): 961-3 PubMed PMID: 19723790 

  AJP Editor's Selection: Editorial - 2009 in Review. Am J Psychiatry. 2009 Dec;166(12): 1318-1321

  Joeyen-Waldorf J, Edgar N, Sibille E. The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice. Brain Res. 2009 Aug 25;1286:84-93. Epub 2009 Jul 3. PubMed PMID: 19577546 

  Edgar N, Sibille E. Genetically modified animals. In I Stolerman (ed) Encyclopedia of Psychopharmacology, Springer-Verlag Publishers. 2010. 

  Oh S, Tseng GC, Sibille E. Reciprocal Phylogenetic Conservation of Molecular Aging in Mouse and Human Brain. Neurobiology of Aging. 2009 Sep 1 [Epub ahead of print] PubMed PMID: 19729224. 

  Romcy-Pereira RN, Erraji-Benchekroun L, Smyrniotopoulos P, Ogawa S, Mello CV, Sibille E, Pavlides C. Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. Physiol Behav. 2009 Aug 4;98(1-2):44-52. Epub 2009 Apr 20. PubMed PMID: 19389414 

  Surget A, Wang, Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E. Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology. 2009 May;34(6):1363-80. Epub 2008 Jun 4. PubMed PMID: 18536703. 


  Sibille E, Joeyen-Waldorf J, Wang Y, Arango V, Mann J, Leman S, Surget A, Belzung C, Lewis, DA. Large-scale estimates of cellular origins of mRNAs: Enhancing the yield of transcriptome analysis. J Neurosci Methods. 2008 Jan 30;167(2):198-206. Epub 2007 Aug 21. PubMed PMID: 17889939 

  Beneyto M,Sibille E, Lewis DA. Human postmortem brain research in mental illness syndromes. In DS Charney, EJ Nestler (eds) Neurobiology of Mental Illness, 3e, Oxford University Press, 2008. 


  Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso CA, Tseng G, Pezzone M, Hen R, Belzung C. Upregulated sirtuin 5 gene expression in frontal cortex of serotonin 1b receptor knock out mice. Mol Psychiatry. 2007;12(11):975. 

  Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso CA, Tseng G, Pezzone M, Hen R, Belzung C. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Mol Psychiatry. 2007 Nov;12(11):1042-56, 975. Epub 2007 Apr 10. PubMed PMID:17420766 

Publications prior to 2007

  Leonardo ED, Richardson-Jones JW, Sibille E, Hen R. Molecular heterogeneity along the dorsal-ventral axis of the murine hippocampal CA1 field: a microarray analysis of gene expression. Neuroscience. 2006;137(1):177-86. Epub 2005 Nov 23. PubMed PMID: 16309847.  

  Sibille E, Lewis D. SERT-ainly involved in depression, but when? Am J Psychiatry. 2006 Jan;163(1):8-11. PubMed PMID: 16390880. 

  Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ,Sibille E, Tamir H, Mann JJ, Arango V. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology. 2006 Apr;31(4):814-24. PubMed PMID:16192985. 

  Weisstaub NV, Zhou M, Lira A, Lambe E, Gonzalez-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA. Cortical 5-HT2A receptor signaling modulates anxiety-like behavior in mice. Science. 2006 Jul 28;313(5786):536-40. PubMed PMID: 16873667. 

  Erraji-Benchekroun L, Underwood MD, Arango V, Galfalvy H, Pavlidis P, Smyrniotopoulos P, Mann JJ, Sibille E. Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry. 2005 Mar 1;57(5):549-58. PubMed PMID: 15737671. 

  Barr GA, Gao P, Wang S, Cheng J, Qin J, Sibille E, Pavlidis P. Microarray analysis of gene expression following the formalin test in the infant rat. Pain. 2005 Sep;117(1-2):6-18. PubMed PMID:16043289. 

  Sibille E, Arango V, Galfalvy H, Pavlidis P, Ellis S, Mann JJ. Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology. 2004 Feb;29(2):351-61. PubMed PMID: 14603265. 

  Pavlidis P, Qin J, Arango V, Mann JJ, Sibille E. Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex. Neurochem Res. 2004 Jun;29(6):1213-22. PubMed PMID: 15176478. 

  Liu W, Seto J, Sibille E, Toth M. RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Mol Cell Bio. 2003 Jun;23(12):4083-93. PubMed PMID: 12773553. 

  Galfalvy H, Erraji-Benchekroun L, Smyrniotopoulos P, Pavlidis P, Ellis S, Mann JJ, Sibille, Arango V. Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction. BMC Bioinformatics. 2003 Sep 8;4:37. Epub 2003 Sep 8. PubMed PMID: 12962547. 

  Galfavy H, Ellis S, Mann JJ, Sibille E. Standardizing gene expression data from high-density oligonucleotide microarrays in a matched pair study. Proc Am Stat Assoc. 2002;12:95-99. 

  Santarelli L, Debs P, Gobbi G, Sibille E, Yamamoto A, Blier P, Hen R, Heath M. Genetic and pharmacological disruption on neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A. 2001; 98:1912-1917.

  Sibille E, Hen R. Serotonin1A receptors in mood disorders. A combined genetic and genomic approach. Behav Pharmacol. 2001 Nov;12(6-7):429-38. PubMed PMID: 11742136. 

  He M, Sibille E, Benjamin D, Toth M, Shippenberg T. Differential effects of 5-HT(1A) receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain Res.2001. May 25;902(1):11-7 PubMed PMID: 11376590. 

  Sibille E, Hen R. Combining genetic and genomic approaches to study mood disorder. Eur Neuropsychopharmacol.2001 Dec;11(6):413-21. PubMed PMID: 11704418.

  Sibille E, Pavlides C, Benke D, Toth M. Genetic inactivation of the Serotonin1A receptor in Mice results in downregulation of major GABAA receptor α subunits, reduction of GABAA receptor binding, and benzodiazepine-resistant anxiety. J Neurosci. 2000 Apr 15;20(8):2758-65. PubMed PMID: 10751426.

Sarnay Z, Sibille E, Pavlides C, Fenster RJ, McEwen BS, Toth M. Functional abnormalities in the hippocampus and impaired hippocampal-dependent learning in mice lacking the 5HT(1A) receptors. CNS Drug Rev 6: 40-40 Suppl. 1, 2000.

  Sarnyai Z, Sibille E, Pavlides C, Fenster R, McEwen BS, Toth M. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking 5-HT1A receptors. Proc Natl Acad Sci U S A. 2000;97:147314-147336.

  Chen L, He M, Sibille E, Thompson A, Sarnyai Z, Baker H, Shippenberg T, Toth M. Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine oxidase B. Neurochem. 1999 Aug;73(2):647-55. PubMed PMID: 10428061. 

  Parks C, Robinson T, Sibille E, Shenk T, Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA. 1998;95:10734-10739. PubMed PMID: 9724773  

  Sibille E, Sarnyai Z, Benjamin D, Gal J, Baker H, Toth M: Antisense Inhibition of 5-Hydroxytryptamin2A Receptor Induces an Antidepressant-Like Effect in Mice. Mol Pharmacol. 1997 Dec;52:1056-1063, 1997  PubMed PMID: 9415715

  Donovan GP, Harden C, Gal J, Ho L, Sibille E, Trifiletti R, Gudas LJ, Toth M: Sensitivity to Jerky gene dosage underlies epileptic seizures in mice. J Neurosci. 1997 Jun 15;17(12):4562-9. PubMed PMID: 9169517.